相互作用
Cisapride + Ribociclib
重症度: 併用禁忌
Cisapride and Ribociclib: contraindicated interaction.
最終更新日
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概要
Ribociclib is a moderate CYP3A4 inhibitor and also prolongs the QT interval in a dose-dependent manner. Combined with cisapride, which is a CYP3A4 substrate with a known risk of torsades de pointes, this could produce serious arrhythmia.
この相互作用をわかりやすく説明すると
Cisapride and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Ribociclib belongs to Oncology.
なぜ起こるのか
Ribociclib inhibits CYP3A4, which may increase cisapride exposure, and both drugs prolong the QT interval additively.
対処法
Avoid the combination and choose a non-QT-prolonging prokinetic or antiemetic. If it cannot be avoided, specialist supervision with ECG and electrolyte monitoring is required.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CisaprideとRibociclibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cisaprideのその他の相互作用
Ribociclibのその他の相互作用
よくある質問
Can I take Cisapride with Ribociclib?
MediHelp rates the interaction as contraindicated. Cisapride and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ribociclib is a moderate CYP3A4 inhibitor and also prolongs the QT interval in a dose-dependent manner. Combined with cisapride, which is a CYP3A4 substrate with a known risk of torsades de pointes, this could produce serious arrhythmia.
How serious is the interaction between Cisapride and Ribociclib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging prokinetic or antiemetic. If it cannot be avoided, specialist supervision with ECG and electrolyte monitoring is required.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
