相互作用
Aripiprazole + Metoclopramide
重症度: 重大
Aripiprazole and Metoclopramide: major interaction.
最終更新日
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概要
Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
この相互作用をわかりやすく説明すると
Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive central dopamine D2 receptor antagonism.
対処法
Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AripiprazoleとMetoclopramideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Metoclopramideのその他の相互作用
Aripiprazoleのその他の相互作用
よくある質問
Can I take Aripiprazole with Metoclopramide?
MediHelp rates the interaction as major. Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
How serious is the interaction between Aripiprazole and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
