相互作用
Milrinone + Ponesimod
重症度: 軽度
Milrinone and Ponesimod: minor interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Ponesimod slows heart rate on initiation, while milrinone is an inotrope with vasodilating and arrhythmogenic properties. No established additive bradycardia exists, but the combination occurs in patients with significant cardiac disease in whom hemodynamic instability is a concern.
この相互作用をわかりやすく説明すると
Milrinone and Ponesimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Milrinone belongs to Cardiovascular; Ponesimod belongs to Central Nervous System.
なぜ起こるのか
No established interaction; the drugs have differing hemodynamic effects via S1P receptor modulation and PDE3 inhibition.
対処法
Monitor heart rate, blood pressure and ECG when ponesimod is started in a patient receiving milrinone, and involve cardiology if there is significant cardiac disease.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MilrinoneとPonesimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Milrinoneのその他の相互作用
Ponesimodのその他の相互作用
よくある質問
Can I take Milrinone with Ponesimod?
MediHelp rates the interaction as minor. Milrinone and Ponesimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponesimod slows heart rate on initiation, while milrinone is an inotrope with vasodilating and arrhythmogenic properties. No established additive bradycardia exists, but the combination occurs in patients with significant cardiac disease in whom hemodynamic instability is a concern.
How serious is the interaction between Milrinone and Ponesimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when ponesimod is started in a patient receiving milrinone, and involve cardiology if there is significant cardiac disease.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Enoximone. The full list is on the Milrinone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
