相互作用
Morphine + Tranylcypromine
重症度: 併用禁忌
Morphine and Tranylcypromine: contraindicated interaction.
最終更新日
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概要
Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.
この相互作用をわかりやすく説明すると
Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Morphine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
なぜ起こるのか
Irreversible MAO inhibition potentiates serotonergic and CNS depressant effects of the opioid.
対処法
Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MorphineとTranylcypromineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Morphineのその他の相互作用
Tranylcypromineのその他の相互作用
よくある質問
Can I take Morphine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Morphine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
