相互作用
Isocarboxazid + Morphine
重症度: 併用禁忌
Isocarboxazid and Morphine: contraindicated interaction.
最終更新日
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概要
Opioids given with MAO inhibitors can cause severe reactions, including serotonin syndrome-like excitation, hyperpyrexia, hypertension or hypotension, and coma. Labeling of nonselective MAOIs advises against co-use with opioids.
この相互作用をわかりやすく説明すると
Isocarboxazid and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
なぜ起こるのか
Nonselective MAO inhibition combined with opioid effects leads to serotonergic toxicity and unpredictable CNS and cardiovascular responses.
対処法
Avoid concurrent use and allow about 14 days after stopping isocarboxazid before giving morphine where possible. Use a non-opioid alternative, and if an opioid is unavoidable, monitor intensively.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IsocarboxazidとMorphineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Morphineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Isocarboxazid with Morphine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors can cause severe reactions, including serotonin syndrome-like excitation, hyperpyrexia, hypertension or hypotension, and coma. Labeling of nonselective MAOIs advises against co-use with opioids.
How serious is the interaction between Isocarboxazid and Morphine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow about 14 days after stopping isocarboxazid before giving morphine where possible. Use a non-opioid alternative, and if an opioid is unavoidable, monitor intensively.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Morphine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
