相互作用
Olanzapine / samidorphan + Oxymorphone
重症度: 併用禁忌
Olanzapine / samidorphan and Oxymorphone: contraindicated interaction.
最終更新日
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概要
Samidorphan is an opioid antagonist that blocks oxymorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Analgesia may fail.
この相互作用をわかりやすく説明すると
Olanzapine / samidorphan and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Pharmacodynamic antagonism at opioid receptors by samidorphan.
対処法
Do not start in patients using opioids; allow at least 7 days opioid-free for short-acting and 14 days for long-acting opioids before starting. Use another antipsychotic if opioids are needed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Olanzapine / samidorphanとOxymorphoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Oxymorphoneのその他の相互作用
よくある質問
Can I take Olanzapine / samidorphan with Oxymorphone?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks oxymorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Analgesia may fail.
How serious is the interaction between Olanzapine / samidorphan and Oxymorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; allow at least 7 days opioid-free for short-acting and 14 days for long-acting opioids before starting. Use another antipsychotic if opioids are needed.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
