相互作用
Isocarboxazid + Oxymorphone
重症度: 併用禁忌
Isocarboxazid and Oxymorphone: contraindicated interaction.
最終更新日
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概要
Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia and agitation. Labeling advises against use during or within 14 days of MAOI therapy.
この相互作用をわかりやすく説明すると
Isocarboxazid and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
なぜ起こるのか
MAO inhibition potentiates opioid CNS effects and may cause serotonergic or autonomic toxicity; the exact mechanism varies by opioid.
対処法
Do not use oxymorphone during or within 14 days after stopping isocarboxazid. Choose a non-opioid or alternative analgesic strategy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、IsocarboxazidとOxymorphoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Oxymorphoneのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Isocarboxazid with Oxymorphone?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia and agitation. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Isocarboxazid and Oxymorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use oxymorphone during or within 14 days after stopping isocarboxazid. Choose a non-opioid or alternative analgesic strategy.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Olanzapine / samidorphan. The full list is on the Oxymorphone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
