相互作用
Prednisone + Smallpox vaccine live
重症度: 併用禁忌
Prednisone and Smallpox vaccine live: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
The live vaccinia vaccine can cause progressive vaccinia or generalized infection in immunosuppressed patients, and prednisone also weakens the immune response to it. The result can be severe vaccine-related disease and reduced protection.
この相互作用をわかりやすく説明すると
Prednisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Corticosteroid-induced immunosuppression permits uncontrolled replication of live vaccinia virus and reduces vaccine response.
対処法
Avoid replicating vaccinia vaccine in patients on immunosuppressive prednisone doses; use a non-replicating vaccine if one is available and indicated. Defer vaccination until steroids have been stopped for an adequate interval, unless the exposure risk is high.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PrednisoneとSmallpox vaccine liveの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Prednisoneのその他の相互作用
よくある質問
Can I take Prednisone with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Prednisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live vaccinia vaccine can cause progressive vaccinia or generalized infection in immunosuppressed patients, and prednisone also weakens the immune response to it. The result can be severe vaccine-related disease and reduced protection.
How serious is the interaction between Prednisone and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid replicating vaccinia vaccine in patients on immunosuppressive prednisone doses; use a non-replicating vaccine if one is available and indicated. Defer vaccination until steroids have been stopped for an adequate interval, unless the exposure risk is high.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
