相互作用
Mifepristone + Prednisone
重症度: 併用禁忌
Mifepristone and Prednisone: contraindicated interaction.
最終更新日
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概要
Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.
この相互作用をわかりやすく説明すると
Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mifepristone belongs to Endocrine; Prednisone belongs to Endocrine.
なぜ起こるのか
Mifepristone antagonizes glucocorticoid receptors, opposing the effect of prednisone.
対処法
Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、MifepristoneとPrednisoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Prednisoneのその他の相互作用
Mifepristoneのその他の相互作用
よくある質問
Can I take Mifepristone with Prednisone?
MediHelp rates the interaction as contraindicated. Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.
How serious is the interaction between Mifepristone and Prednisone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Radium-223 dichloride. The full list is on the Prednisone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
