相互作用
Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline
重症度: 中等度
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline: moderate interaction.
最終更新日
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概要
Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.
この相互作用をわかりやすく説明すると
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Antibiotic suppression of colonic bacteria needed to convert picosulfate to its active metabolite.
対処法
Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Sodium picosulfate / magnesium oxide / anhydrous citric acidとTigecyclineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tigecyclineのその他の相互作用
よくある質問
Can I take Sodium picosulfate / magnesium oxide / anhydrous citric acid with Tigecycline?
MediHelp rates the interaction as moderate. Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.
How serious is the interaction between Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
