医薬品リファレンス
Tigecycline
Tigecycline is a medicine in the class anti bacterial. It is used for intra-abdominal infections.
- 薬効分類: Anti Bacterial
- 効能・効果: intra-abdominal infections
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Bacterial
- ATCコード
- J01AA12
- 一般的な剤形
- 注射剤, 点滴静注剤
- 一般的な規格
- 50 mg, 50 mg/5 ml
- 既知の相互作用
- 17 (重大: 1 · 中等度: 5 · 軽度: 11)
- 商品名
- 12
- 国・市場
- 5
何に使われるか
作用のしくみ
A glycylcycline antibiotic that is structurally similar to tetracycline antibiotics; inhibits bacterial protein translation by binding to 30S ribosomal subunit, and blocks entry of amino-acyl tRNA molecules in ribosome A site.
成人の通常用量（添付文書の要約）
Complicated Intra-abdominal Infections (Initial): 100 mg IV infusion, THEN 50 mg IV infusion q12hr for 5-14 days
妊娠と授乳
- 妊娠
- Unsafe Like other tetracyclines it may permanently discolour the baby's teeth and slow bone growth when given in the 2nd or 3rd trimester; skeletal delays in rats and rabbits at 1 to 5 times human exposure. UK label: do not use unless the mother's condition requires it. Prefer another antibiotic.
- 授乳
- Safe No human milk data; poorly absorbed orally, so infant exposure is expected to be low. US label: avoid breastfeeding for courses over 3 weeks; may pump and discard during and for 9 days after. LactMed: short courses probably acceptable; watch for rash, diarrhoea or thrush.
報告されている副作用
- Vomiting
- Diarrhea
- Nausea
- Infection
- Fever
注意が必要な方
- Prescribing therapy in absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to patient
- May cause fetal harm when administered to a pregnant woman
- Increases in total bilirubin concentration, prothrombin time and transaminases reported in patients treated with tigecycline;
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (17)
- Tigecycline + Typhoid vaccine live Major
- Bcg vaccine live + Tigecycline Moderate
- Cholera vaccine + Tigecycline Moderate
- Microbiota + Tigecycline Moderate
- Mipomersen + Tigecycline Moderate
- Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline Moderate
- Balsalazide + Tigecycline Minor
- Bazedoxifene / conjugated estrogens + Tigecycline Minor
- Conjugated estrogens + Tigecycline Minor
- Desogestrel-ethinyl estradiol + Tigecycline Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Tigecyclineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Tigecycline used for?
Tigecycline is a medicine in the class anti bacterial. It is used for Intra-abdominal infections, Pneumonia, Skin infections.
What side effects have been reported with Tigecycline?
Vomiting, Diarrhea, Nausea, Infection, Fever.
Can Tigecycline be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Like other tetracyclines it may permanently discolour the baby's teeth and slow bone growth when given in the 2nd or 3rd trimester; skeletal delays in rats and rabbits at 1 to 5 times human exposure. UK label: do not use unless the mother's condition requires it. Prefer another antibiotic. Breastfeeding: Safe. No human milk data; poorly absorbed orally, so infant exposure is expected to be low. US label: avoid breastfeeding for courses over 3 weeks; may pump and discard during and for 9 days after. LactMed: short courses probably acceptable; watch for rash, diarrhoea or thrush.
What does Tigecycline interact with?
MediHelp lists 17 known interactions for Tigecycline. Major: 1 · Moderate: 5 · Minor: 11. The most serious include Typhoid vaccine live, Bcg vaccine live, Cholera vaccine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
