相互作用
Tigecycline + Typhoid vaccine live
重症度: 重大
Tigecycline and Typhoid vaccine live: major interaction.
最終更新日
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概要
Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
この相互作用をわかりやすく説明すると
Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Antibacterial activity kills or inhibits the live attenuated Salmonella strain, reducing colonisation and immunogenicity.
対処法
Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、TigecyclineとTyphoid vaccine liveの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tigecyclineのその他の相互作用
よくある質問
Can I take Tigecycline with Typhoid vaccine live?
MediHelp rates the interaction as major. Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
How serious is the interaction between Tigecycline and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Bcg vaccine live, Cholera vaccine, Microbiota. The full list is on the Tigecycline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
