相互作用
Talimogene laherparepvec + Valganciclovir
重症度: 重大
Talimogene laherparepvec and Valganciclovir: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Talimogene laherparepvec is a live, attenuated herpes simplex virus that depends on replication. Valganciclovir is converted to ganciclovir, which is active against herpes viruses and may reduce the efficacy of the oncolytic virus.
この相互作用をわかりやすく説明すると
Talimogene laherparepvec and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Talimogene laherparepvec belongs to Oncology; Valganciclovir belongs to Anti Virals.
なぜ起こるのか
Antiviral inhibition of viral DNA replication, which may blunt the live oncolytic virus.
対処法
Avoid antiherpetic antivirals during talimogene therapy where possible. If treatment of a herpetic infection is required, treat it and reassess the oncolytic regimen.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Talimogene laherparepvecとValganciclovirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Valganciclovirのその他の相互作用
Talimogene laherparepvecのその他の相互作用
よくある質問
Can I take Talimogene laherparepvec with Valganciclovir?
MediHelp rates the interaction as major. Talimogene laherparepvec and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talimogene laherparepvec is a live, attenuated herpes simplex virus that depends on replication. Valganciclovir is converted to ganciclovir, which is active against herpes viruses and may reduce the efficacy of the oncolytic virus.
How serious is the interaction between Talimogene laherparepvec and Valganciclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antiherpetic antivirals during talimogene therapy where possible. If treatment of a herpetic infection is required, treat it and reassess the oncolytic regimen.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
