相互作用
Ganciclovir + Talimogene laherparepvec
重症度: 重大
Ganciclovir and Talimogene laherparepvec: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Talimogene laherparepvec is a live, attenuated herpes simplex virus that must replicate in tumor cells. Ganciclovir is active against herpes viruses and may suppress this replication, reducing the efficacy of the oncolytic therapy.
この相互作用をわかりやすく説明すると
Ganciclovir and Talimogene laherparepvec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ganciclovir belongs to Anti Virals; Talimogene laherparepvec belongs to Oncology.
なぜ起こるのか
Antiviral inhibition of viral DNA replication, which may blunt the activity of the live oncolytic virus.
対処法
Avoid antiherpetic antivirals during talimogene therapy where possible. If ganciclovir is needed for a herpes infection, such as an infection attributed to the vector, treat it and reassess the oncolytic regimen.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GanciclovirとTalimogene laherparepvecの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ganciclovirのその他の相互作用
Talimogene laherparepvecのその他の相互作用
よくある質問
Can I take Ganciclovir with Talimogene laherparepvec?
MediHelp rates the interaction as major. Ganciclovir and Talimogene laherparepvec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talimogene laherparepvec is a live, attenuated herpes simplex virus that must replicate in tumor cells. Ganciclovir is active against herpes viruses and may suppress this replication, reducing the efficacy of the oncolytic therapy.
How serious is the interaction between Ganciclovir and Talimogene laherparepvec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antiherpetic antivirals during talimogene therapy where possible. If ganciclovir is needed for a herpes infection, such as an infection attributed to the vector, treat it and reassess the oncolytic regimen.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
