Interações medicamentosas
Daridorexant + Posaconazole
Gravidade: Grave
Daridorexant and Posaconazole: major interaction.
Última atualização Fontes: UK SmPC
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Resumo
Posaconazole markedly increases daridorexant exposure, which may cause excessive sedation, next-day impairment and somnolence. Labeling advises against use with strong CYP3A4 inhibitors.
O que esta interação significa em palavras simples
Daridorexant and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Por que acontece
Strong CYP3A4 inhibition by posaconazole reduces daridorexant clearance.
O que fazer
Avoid concomitant use and select a different insomnia treatment during posaconazole therapy. Counsel on next-day drowsiness if exposure occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
- Noxafil 100 mg Gastro-resistant Tablets - SmPC sections 4.3/4.5 (class statement: CYP3A4 substrates; "Posaconazole is a potent inhibitor of CYP3A4. Co-administration of posaconazole with CYP3A4 substrates may result in large increases in exposure to CYP3A4 subst") — electronic medicines compendium (UK SmPC)
Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Conivaptan + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dihydroergotamine + Posaconazole Contraindicada
Outras interações de Daridorexant
Perguntas frequentes
Can I take Daridorexant with Posaconazole?
MediHelp rates the interaction as major. Daridorexant and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole markedly increases daridorexant exposure, which may cause excessive sedation, next-day impairment and somnolence. Labeling advises against use with strong CYP3A4 inhibitors.
How serious is the interaction between Daridorexant and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select a different insomnia treatment during posaconazole therapy. Counsel on next-day drowsiness if exposure occurs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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