Interações medicamentosas
Daridorexant + Phenytoin
Gravidade: Grave
Daridorexant and Phenytoin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Phenytoin is expected to markedly lower daridorexant exposure, reducing its hypnotic effect.
O que esta interação significa em palavras simples
Daridorexant and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
Por que acontece
CYP3A4 induction by phenytoin increases daridorexant clearance.
O que fazer
Avoid the combination, as labeling advises against strong CYP3A4 inducers. Consider a different insomnia treatment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Outras interações de Daridorexant
Perguntas frequentes
Can I take Daridorexant with Phenytoin?
MediHelp rates the interaction as major. Daridorexant and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin is expected to markedly lower daridorexant exposure, reducing its hypnotic effect.
How serious is the interaction between Daridorexant and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as labeling advises against strong CYP3A4 inducers. Consider a different insomnia treatment.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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