Referência de medicamentos
Liothyronine
Liothyronine is a medicine in the class endocrine. It is used for hypothyroidism.
- Classe do medicamento: Endocrine
- Indicado para: hypothyroidism
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Endocrine
- Formas farmacêuticas comuns
- comprimido
- Interações conhecidas
- 53 (Moderada: 41 · Leve: 12)
- Nomes comerciais
- 2
- Países e mercados
- 1
Para que é usado
Como funciona
Thyroid hormones act by controlling DNA transcription and protein synthesis. T3 and T4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA, activating gene transcription and messenger RNA synthesis.
Dose habitual em adultos (resumo da bula)
Hypothyroidism: start 25 mcg orally once daily; increase by 25 mcg daily every 1 or 2 weeks if needed; usual maintenance 25 mcg to 75 mcg once daily
Gravidez e amamentação
- Gravidez
- Safe Post-marketing data have not shown more birth defects or miscarriage. Untreated hypothyroidism harms mother and fetus, so do not stop treatment: check TSH and adjust the dose during pregnancy. Levothyroxine is the usual first choice in pregnancy.
- Amamentação
- Safe Liothyronine (T3) is a normal component of milk; replacement doses are not a reason to stop breastfeeding (LactMed). US label: weigh benefits (insufficient data on infant effects). Levothyroxine is recommended for hypothyroidism while breastfeeding.
Efeitos adversos relatados
- Arrhythmias
- Headache
- Nervousness
- Insomnia
- Tremors
- Weight loss
Advertências de caixa preta
- Not for treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening toxicity, particularly with sympathomimetic amines.
Contraindicações
- Uncorrected adrenal insufficiency
Quem deve ter cuidado
- Cardiac adverse reactions in the elderly and patients with cardiovascular disease; start at lower doses
- Not for myxedema coma; use intravenous thyroid hormone products
- Acute adrenal crisis in adrenal insufficiency; give glucocorticoids first
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (53)
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
- Clomipramine + Liothyronine Moderate
- Colesevelam + Liothyronine Moderate
- Dapagliflozin-metformin + Liothyronine Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
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- Pharmacokinetics
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Outros medicamentos desta classe
Perguntas frequentes
What is Liothyronine used for?
Liothyronine is a medicine in the class endocrine. It is used for Hypothyroidism, Thyroid cancer.
What side effects have been reported with Liothyronine?
Arrhythmias, Headache, Nervousness, Insomnia, Tremors, Weight loss. Serious warning: Not for treatment of obesity or for weight loss.
Can Liothyronine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Post-marketing data have not shown more birth defects or miscarriage. Untreated hypothyroidism harms mother and fetus, so do not stop treatment: check TSH and adjust the dose during pregnancy. Levothyroxine is the usual first choice in pregnancy. Breastfeeding: Safe. Liothyronine (T3) is a normal component of milk; replacement doses are not a reason to stop breastfeeding (LactMed). US label: weigh benefits (insufficient data on infant effects). Levothyroxine is recommended for hypothyroidism while breastfeeding.
What does Liothyronine interact with?
MediHelp lists 53 known interactions for Liothyronine. Moderate: 41 · Minor: 12. The most serious include Alogliptin-metformin, Amitriptyline, Amobarbital.
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