Interações medicamentosas
Amitriptyline + Liothyronine
Gravidade: Moderada
Amitriptyline and Liothyronine: moderate interaction.
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Resumo
Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
O que esta interação significa em palavras simples
Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Por que acontece
Increased adrenergic receptor sensitivity from thyroid hormone augments tricyclic cardiovascular and CNS effects.
O que fazer
Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Liothyronine
- Alogliptin-metformin + Liothyronine Moderada
- Amobarbital + Liothyronine Moderada
- Canagliflozin-metformin + Liothyronine Moderada
- Carbamazepine + Liothyronine Moderada
- Carbonyl iron + Liothyronine Moderada
- Cholestyramine + Liothyronine Moderada
Perguntas frequentes
Can I take Amitriptyline with Liothyronine?
MediHelp rates the interaction as moderate. Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
How serious is the interaction between Amitriptyline and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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