Referência de medicamentos
Lipegfilgrastim
Lipegfilgrastim is a medicine in the class miscellaneous. It is used for febrile neutropenia.
- Classe do medicamento: Miscellaneous
- Indicado para: febrile neutropenia
Última atualização Fontes: EMA SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Miscellaneous
- Código ATC
- L03AA14
- Concentrações comuns
- 6 mg
- Nomes comerciais
- 2
- Países e mercados
- 2
Para que é usado
Como funciona
Lipegfilgrastim is a PEGylated conjugate of filgrastim (recombinant methionyl human G-CSF) that binds the G-CSF receptor. It stimulates proliferation and differentiation of haematopoietic progenitor cells and release of neutrophils into the blood.
Dose habitual em adultos (resumo da bula)
Reduction in duration of neutropenia and febrile neutropenia with cytotoxic chemotherapy: 6 mg (0.6 ml), subcutaneous, once for each chemotherapy cycle, given approximately 24 hours after cytotoxic chemotherapy
Gravidez e amamentação
- Gravidez
- Unknown Very limited human data (fewer than 300 pregnancies); animal studies showed reproductive toxicity. UK label: as a precaution, preferably avoid in pregnancy. Filgrastim has more pregnancy data and may be preferred.
- Amamentação
- Unknown Not known if it passes into milk. No LactMed record; related G-CSFs (filgrastim) pass poorly into milk and are not absorbed by the infant, but this long-acting form has no data. UK label: stop breastfeeding during treatment (risk cannot be excluded).
Efeitos adversos relatados
- Musculoskeletal pain
- Nausea
- Thrombocytopenia
- Hypokalaemia
- Headache
- Haemoptysis
Contraindicações
- Hypersensitivity to the active substance or to any excipient.
Quem deve ter cuidado
- Cross-reactivity: patients hypersensitive to G-CSF or derivatives should not start lipegfilgrastim.
- Not to be used to increase chemotherapy dose beyond established regimens; not investigated with high dose chemotherapy.
- Thrombocytopenia and leukocytosis may occur; monitor platelet count, haematocrit and WBC regularly.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para abrir a monografia completa de Lipegfilgrastim: doses, gravidez e amamentação, efeitos adversos, advertências e todas as interações.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outros medicamentos desta classe
Perguntas frequentes
What is Lipegfilgrastim used for?
Lipegfilgrastim is a medicine in the class miscellaneous. It is used for Febrile neutropenia, Neutropenia.
What side effects have been reported with Lipegfilgrastim?
Musculoskeletal pain, Nausea, Thrombocytopenia, Hypokalaemia, Headache, Haemoptysis.
Can Lipegfilgrastim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Very limited human data (fewer than 300 pregnancies); animal studies showed reproductive toxicity. UK label: as a precaution, preferably avoid in pregnancy. Filgrastim has more pregnancy data and may be preferred. Breastfeeding: Unknown. Not known if it passes into milk. No LactMed record; related G-CSFs (filgrastim) pass poorly into milk and are not absorbed by the infant, but this long-acting form has no data. UK label: stop breastfeeding during treatment (risk cannot be excluded).
What does Lipegfilgrastim interact with?
MediHelp does not list a checked interaction for Lipegfilgrastim yet. Always tell your pharmacist about every medicine you take.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
