Referência de medicamentos
Luspatercept
Luspatercept is a medicine in the class miscellaneous. It is used for anemia.
- Classe do medicamento: Miscellaneous
- Indicado para: anemia
Última atualização Fontes: US FDA label
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Pontos-chave
- Classe do medicamento
- Miscellaneous
- Código ATC
- B03XA06
- Formas farmacêuticas comuns
- injeção
- Concentrações comuns
- 25 mg
- Nomes comerciais
- 3
- Países e mercados
- 3
Para que é usado
Como funciona
Recombinant fusion protein that binds several endogenous TGF-β superfamily ligands, diminishing Smad2/3 signaling and promoting erythroid maturation, thereby increasing erythropoiesis.
Dose habitual em adultos (resumo da bula)
Beta thalassemia anemia requiring regular RBC transfusions: start 1 mg/kg subcutaneously once every 3 weeks; increase to 1.25 mg/kg if no reduction in RBC transfusion burden; maximum 1.25 mg/kg
Gravidez e amamentação
- Gravidez
- Unsafe May cause fetal harm: in rats and rabbits it caused fetal death, poor growth and malformations. No human data. Do not use in pregnancy; women who could become pregnant need a pregnancy test before starting and effective contraception during treatment and for 3 months after.
- Amamentação
- Unknown No human milk data; it passes into rat milk. LactMed: as a large protein, milk levels are likely very low and poorly absorbed, but no data yet. US label: breastfeeding not recommended during treatment and for 3 months after the last dose.
Efeitos adversos relatados
- Fatigue
- Headache
- Musculoskeletal pain
- Arthralgia
- Dizziness/vertigo
- Nausea
Quem deve ter cuidado
- Thromboembolic events reported in beta thalassemia; consider thromboprophylaxis in at-risk patients and monitor.
- Hypertension: monitor blood pressure before each administration and treat with antihypertensives.
- Extramedullary hematopoietic masses in beta thalassemia; monitor and discontinue for serious complications.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Perguntas frequentes
What is Luspatercept used for?
Luspatercept is a medicine in the class miscellaneous. It is used for Anemia, Myelodysplastic syndromes, Thalassemia.
What side effects have been reported with Luspatercept?
Fatigue, Headache, Musculoskeletal pain, Arthralgia, Dizziness/vertigo, Nausea.
Can Luspatercept be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm: in rats and rabbits it caused fetal death, poor growth and malformations. No human data. Do not use in pregnancy; women who could become pregnant need a pregnancy test before starting and effective contraception during treatment and for 3 months after. Breastfeeding: Unknown. No human milk data; it passes into rat milk. LactMed: as a large protein, milk levels are likely very low and poorly absorbed, but no data yet. US label: breastfeeding not recommended during treatment and for 3 months after the last dose.
What does Luspatercept interact with?
MediHelp does not list a checked interaction for Luspatercept yet. Always tell your pharmacist about every medicine you take.
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