Referência de medicamentos
Miconazole
Miconazole is a medicine in the class anti fungals. It is used for oropharyngeal candidiasis.
- Classe do medicamento: Anti Fungals
- Indicado para: oropharyngeal candidiasis
Última atualização Fontes: US FDA label, UK SmPC, Base de donnees publique des medicaments (France), ANSM Base de donnees publique des medicaments (RCP, French)
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Anti Fungals
- Formas farmacêuticas comuns
- creme, pó, gel, inalador, pomada, solução
- Concentrações comuns
- 2 g/100 g, 2%, 20 mg/g
- Interações conhecidas
- 50 (Grave: 12 · Moderada: 24 · Leve: 14)
- Nomes comerciais
- 232
- Países e mercados
- 5
Para que é usado
Como funciona
Azole antifungal agent; inhibits enzyme cytochrome P450 14-alpha-demethylase resulting in ergosterol synthesis inhibition
Dose habitual em adultos (resumo da bula)
Oropharyngeal Candidiasis: Apply 50 mg buccal tab to gum region qDay for 14 consecutive days
Gravidez e amamentação
- Gravidez
- Unknown Vaginal and skin forms: little is absorbed; topical azoles are preferred for thrush in pregnancy. Oral gel and buccal tablets are more absorbed; the buccal label warns of possible fetal harm from animal data, so avoid them if possible (nystatin is an option for mouth thrush).
- Amamentação
- Safe No data for buccal tablets. Poorly absorbed from skin, vagina and gut, so unlikely to affect the infant (LactMed), including when used on the nipples; remove excess before feeds and prefer creams or gels to ointments on the breast.
Efeitos adversos relatados
- Irritation
- Diarrhea
- Nausea
- Allergic contact dermatitis
- Burning
Contraindicações
- Hypersensitivity to drug, milk protein concentrate, or other excipients
Quem deve ter cuidado
- Miconazole is systemically absorbed and inhibits CYP2C9 and CYP3A4, prolonging the effect of warfarin; bleeding events, some fatal, have been reported with oral gel. Monitor the anticoagulant effect carefully if coumarin anticoagulants are used concomitantly.
- Choking risk in infants and young children (4 months to 2 years): do not apply the gel to the back of the throat, divide each dose into small portions and observe the patient. Do not apply it to a nipple for infant administration.
- Severe hypersensitivity reactions including anaphylaxis and angioedema have been reported; stop treatment if hypersensitivity or irritation occurs.
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Principais interações (50)
- Cabazitaxel + Miconazole Major
- Dihydroergotamine + Miconazole Major
- Dihydroergotamine intranasal + Miconazole Major
- Ergotamine + Miconazole Major
- Glyburide + Miconazole Major
- Lovastatin + Miconazole Major
- Methadone + Miconazole Major
- Miconazole + Pimozide Major
- Miconazole + Ribociclib Major
- Miconazole + Simvastatin Major
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- Renal and hepatic dose adjustments
- Paediatric dosing
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- Pharmacokinetics
- Patient counselling points
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Outros medicamentos desta classe
Perguntas frequentes
What is Miconazole used for?
Miconazole is a medicine in the class anti fungals. It is used for Oropharyngeal candidiasis, Tinea, Vulvovaginal candidiasis.
What side effects have been reported with Miconazole?
Irritation, Diarrhea, Nausea, Allergic contact dermatitis, Burning.
Can Miconazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Vaginal and skin forms: little is absorbed; topical azoles are preferred for thrush in pregnancy. Oral gel and buccal tablets are more absorbed; the buccal label warns of possible fetal harm from animal data, so avoid them if possible (nystatin is an option for mouth thrush). Breastfeeding: Safe. No data for buccal tablets. Poorly absorbed from skin, vagina and gut, so unlikely to affect the infant (LactMed), including when used on the nipples; remove excess before feeds and prefer creams or gels to ointments on the breast.
What does Miconazole interact with?
MediHelp lists 50 known interactions for Miconazole. Major: 12 · Moderate: 24 · Minor: 14. The most serious include Cabazitaxel, Dihydroergotamine, Dihydroergotamine intranasal.
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