Interações medicamentosas
Ergotamine + Miconazole
Gravidade: Grave
Ergotamine and Miconazole: major interaction.
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Resumo
Miconazole is a CYP3A4 inhibitor, but only oral-gel or systemic dosing yields meaningful exposure; vaginal or topical use is minimally absorbed. With systemic exposure, ergotamine levels can rise and cause vasospasm.
O que esta interação significa em palavras simples
Ergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Miconazole belongs to Anti Fungals.
Por que acontece
CYP3A4 inhibition raising ergotamine exposure (clinically relevant with systemic miconazole)
O que fazer
Avoid with systemic or buccal miconazole; topical and vaginal use carries little risk.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Miconazole
Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Perguntas frequentes
Can I take Ergotamine with Miconazole?
MediHelp rates the interaction as major. Ergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Miconazole is a CYP3A4 inhibitor, but only oral-gel or systemic dosing yields meaningful exposure; vaginal or topical use is minimally absorbed. With systemic exposure, ergotamine levels can rise and cause vasospasm.
How serious is the interaction between Ergotamine and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with systemic or buccal miconazole; topical and vaginal use carries little risk.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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