Interações medicamentosas
Glyburide + Miconazole
Gravidade: Grave
Glyburide and Miconazole: major interaction.
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Resumo
Glyburide is metabolized by CYP2C9 and CYP3A4, both inhibited by miconazole. Increased levels can cause severe and prolonged hypoglycemia, and cases have been reported with miconazole. The risk is greater in elderly patients and those with renal impairment.
O que esta interação significa em palavras simples
Glyburide and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide belongs to Endocrine; Miconazole belongs to Anti Fungals.
Por que acontece
Miconazole inhibits CYP2C9 and CYP3A4, reducing glyburide clearance.
O que fazer
Monitor blood glucose frequently and counsel on hypoglycemia symptoms. Reduce the glyburide dose or switch to a non-azole antifungal or alternative agent if feasible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Miconazole
Outras interações de Glyburide
- Bosentan + Glyburide Contraindicada
- Cholic acid + Glyburide Grave
- Ciprofloxacin + Glyburide Grave
- Clarithromycin + Glyburide Grave
- Fluconazole + Glyburide Grave
- Glyburide + Insulin degludec-liraglutide Grave
Perguntas frequentes
Can I take Glyburide with Miconazole?
MediHelp rates the interaction as major. Glyburide and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide is metabolized by CYP2C9 and CYP3A4, both inhibited by miconazole. Increased levels can cause severe and prolonged hypoglycemia, and cases have been reported with miconazole. The risk is greater in elderly patients and those with renal impairment.
How serious is the interaction between Glyburide and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and counsel on hypoglycemia symptoms. Reduce the glyburide dose or switch to a non-azole antifungal or alternative agent if feasible.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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