Interações medicamentosas
Cabazitaxel + Miconazole
Gravidade: Grave
Cabazitaxel and Miconazole: major interaction.
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Resumo
Systemic miconazole inhibits CYP3A4 and may substantially raise cabazitaxel exposure, increasing the risk of severe neutropenia. Topical or buccal use produces less systemic effect, but oral gel can still be absorbed.
O que esta interação significa em palavras simples
Cabazitaxel and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Miconazole belongs to Anti Fungals.
Por que acontece
Miconazole inhibits CYP3A4, reducing cabazitaxel metabolism.
O que fazer
Avoid systemic miconazole, using a non-inhibiting antifungal; if unavoidable, monitor blood counts closely and consider reducing the cabazitaxel dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cabazitaxel
Outras interações de Miconazole
Perguntas frequentes
Can I take Cabazitaxel with Miconazole?
MediHelp rates the interaction as major. Cabazitaxel and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic miconazole inhibits CYP3A4 and may substantially raise cabazitaxel exposure, increasing the risk of severe neutropenia. Topical or buccal use produces less systemic effect, but oral gel can still be absorbed.
How serious is the interaction between Cabazitaxel and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic miconazole, using a non-inhibiting antifungal; if unavoidable, monitor blood counts closely and consider reducing the cabazitaxel dose.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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