Referência de medicamentos
Vonoprazan
Vonoprazan is a medicine in the class gastrointestinal tract. It is used for gerd.
- Classe do medicamento: Gastrointestinal Tract
- Indicado para: gerd
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Gastrointestinal Tract
- Formas farmacêuticas comuns
- comprimido
- Concentrações comuns
- 20 mg, 10 mg
- Interações conhecidas
- 42 (Grave: 6 · Moderada: 26 · Leve: 10)
- Nomes comerciais
- 10
- Países e mercados
- 2
Para que é usado
Como funciona
Vonoprazan suppresses basal and stimulated gastric acid secretion by inhibiting the H+,K+-ATPase enzyme system in parietal cells in a potassium-competitive manner. It binds to active pumps noncovalently and reversibly and does not require activation by acid.
Dose habitual em adultos (resumo da bula)
Healing of erosive esophagitis: 20 mg orally once daily for 8 weeks
Como costuma ser tomado
Proton pump inhibitors are usually taken by mouth once a day, often before a meal, for a course whose length depends on the reason for treatment.
Gravidez e amamentação
- Gravidez
- Unknown No adequate and well-controlled studies in pregnant women; available data are insufficient to evaluate drug-associated risk. A pregnancy exposure registry exists.
- Amamentação
- Unknown Vonoprazan is present in breast milk at less than 0.03% of the maternal dose. No data on effects on the breastfed child. Animal liver injury occurred in offspring. Weigh benefits of breastfeeding against maternal need.
Efeitos adversos relatados
- Gastritis
- Diarrhea
- Abdominal pain
- Nausea
- Abdominal distension
- Dyspepsia
Contraindicações
- Known hypersensitivity to vonoprazan or any component of the product (reactions have included anaphylactic shock)
- Concomitant use with rilpivirine-containing products
Quem deve ter cuidado
- Symptomatic response does not preclude gastric malignancy; consider further follow-up and testing, and endoscopy in older patients.
- Acute tubulointerstitial nephritis: discontinue and evaluate if suspected.
- May increase risk of Clostridioides difficile-associated diarrhea; use the shortest duration appropriate.
People taking proton pump inhibitors for a long time should have the need for treatment reviewed, because long-term use is linked to low magnesium, vitamin B12 deficiency, bone fractures and gut infections. Tell your pharmacist about all other medicines, since some interact.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (42)
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
- Armodafinil + Vonoprazan Moderate
- Bosentan + Vonoprazan Moderate
- Carbonyl iron + Vonoprazan Moderate
- Cilostazol + Vonoprazan Moderate
Para assinantes do Pro+
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Outros medicamentos desta classe
Perguntas frequentes
What is Vonoprazan used for?
Vonoprazan is a medicine in the class gastrointestinal tract. It is used for GERD, Heartburn, Helicobacter pylori bacteria.
What side effects have been reported with Vonoprazan?
Gastritis, Diarrhea, Abdominal pain, Nausea, Abdominal distension, Dyspepsia.
Can Vonoprazan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate and well-controlled studies in pregnant women; available data are insufficient to evaluate drug-associated risk. A pregnancy exposure registry exists. Breastfeeding: Unknown. Vonoprazan is present in breast milk at less than 0.03% of the maternal dose. No data on effects on the breastfed child. Animal liver injury occurred in offspring. Weigh benefits of breastfeeding against maternal need.
What does Vonoprazan interact with?
MediHelp lists 42 known interactions for Vonoprazan. Major: 6 · Moderate: 26 · Minor: 10. The most serious include Amobarbital, Apalutamide, Atazanavir.
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