Interações medicamentosas
Carbamazepine + Vonoprazan
Gravidade: Grave
Carbamazepine and Vonoprazan: major interaction.
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Resumo
Carbamazepine may reduce vonoprazan exposure and diminish acid suppression. This could lead to reduced healing or treatment failure of acid-related disease or H. pylori regimens.
O que esta interação significa em palavras simples
Carbamazepine and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Por que acontece
Carbamazepine induces CYP3A4, which is a metabolic pathway for vonoprazan.
O que fazer
Avoid combining with strong CYP3A4 inducers as advised in labeling. Use an alternative acid suppressant such as a proton pump inhibitor and monitor response.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicada
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
Outras interações de Vonoprazan
- Amobarbital + Vonoprazan Grave
- Apalutamide + Vonoprazan Grave
- Atazanavir + Vonoprazan Grave
- Erlotinib + Vonoprazan Grave
- Phenytoin + Vonoprazan Grave
- Armodafinil + Vonoprazan Moderada
Perguntas frequentes
Can I take Carbamazepine with Vonoprazan?
MediHelp rates the interaction as major. Carbamazepine and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine may reduce vonoprazan exposure and diminish acid suppression. This could lead to reduced healing or treatment failure of acid-related disease or H. pylori regimens.
How serious is the interaction between Carbamazepine and Vonoprazan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A4 inducers as advised in labeling. Use an alternative acid suppressant such as a proton pump inhibitor and monitor response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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