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Interações medicamentosas

Armodafinil + Vonoprazan

Gravidade: Moderada

Armodafinil and Vonoprazan: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Armodafinil may reduce vonoprazan exposure through CYP3A4 induction. This may diminish acid suppression and treatment efficacy. The effect is predicted from the mechanism and is greater with strong inducers.

O que esta interação significa em palavras simples

Armodafinil and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Armodafinil belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.

Nível de evidência: Low

Por que acontece

CYP3A4 induction by armodafinil increases the metabolism of vonoprazan, a partial CYP3A4 substrate.

O que fazer

Monitor for reduced acid suppression or symptom control. Consider an alternative acid suppressant if the response is inadequate.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Armodafinil with Vonoprazan?

MediHelp rates the interaction as moderate. Armodafinil and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce vonoprazan exposure through CYP3A4 induction. This may diminish acid suppression and treatment efficacy. The effect is predicted from the mechanism and is greater with strong inducers.

How serious is the interaction between Armodafinil and Vonoprazan?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced acid suppression or symptom control. Consider an alternative acid suppressant if the response is inadequate.

What other medicines interact with Armodafinil?

MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.

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