Interações medicamentosas
Abatacept + Certolizumab pegol
Gravidade: Grave
Abatacept and Certolizumab pegol: major interaction.
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Resumo
Combining a TNF inhibitor with abatacept increases serious infections without a consistent efficacy gain. Labeling for both classes discourages this combination.
O que esta interação significa em palavras simples
Abatacept and Certolizumab pegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abatacept belongs to Musculoskeletal; Certolizumab pegol belongs to Musculoskeletal.
Por que acontece
Additive immunosuppression from TNF-alpha blockade and T-cell costimulation blockade.
O que fazer
Avoid concurrent use of these biologics and switch rather than combine. Monitor for infection during any transition period.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicada
- Bcg intravesical live + Certolizumab pegol Contraindicada
- Bcg vaccine live + Certolizumab pegol Contraindicada
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicada
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicada
Outras interações de Abatacept
Perguntas frequentes
Can I take Abatacept with Certolizumab pegol?
MediHelp rates the interaction as major. Abatacept and Certolizumab pegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a TNF inhibitor with abatacept increases serious infections without a consistent efficacy gain. Labeling for both classes discourages this combination.
How serious is the interaction between Abatacept and Certolizumab pegol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of these biologics and switch rather than combine. Monitor for infection during any transition period.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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