Interações medicamentosas
Acalabrutinib + Dexlansoprazole
Gravidade: Grave
Acalabrutinib and Dexlansoprazole: major interaction.
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Resumo
Acalabrutinib capsules need an acidic stomach to dissolve, and dexlansoprazole raises gastric pH for a prolonged period. This can substantially reduce acalabrutinib absorption and may reduce efficacy.
O que esta interação significa em palavras simples
Acalabrutinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Por que acontece
PPI-induced rise in gastric pH reduces acalabrutinib capsule solubility and absorption.
O que fazer
Avoid the PPI where possible; use an antacid 2 hours apart or an H2 blocker 2 hours after acalabrutinib. The tablet formulation can be used if a PPI is required.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Atazanavir + Dexlansoprazole Grave
- Dacomitinib + Dexlansoprazole Grave
- Dasatinib + Dexlansoprazole Grave
- Dexlansoprazole + Erlotinib Grave
Outras interações de Acalabrutinib
Perguntas frequentes
Can I take Acalabrutinib with Dexlansoprazole?
MediHelp rates the interaction as major. Acalabrutinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib capsules need an acidic stomach to dissolve, and dexlansoprazole raises gastric pH for a prolonged period. This can substantially reduce acalabrutinib absorption and may reduce efficacy.
How serious is the interaction between Acalabrutinib and Dexlansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI where possible; use an antacid 2 hours apart or an H2 blocker 2 hours after acalabrutinib. The tablet formulation can be used if a PPI is required.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Dexlansoprazole page.
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