Interações medicamentosas
Atazanavir + Dexlansoprazole
Gravidade: Grave
Atazanavir and Dexlansoprazole: major interaction.
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Resumo
Atazanavir absorption depends on gastric acidity, and dexlansoprazole can markedly lower atazanavir concentrations. This risks loss of virologic suppression and resistance.
O que esta interação significa em palavras simples
Atazanavir and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Dexlansoprazole belongs to Gastrointestinal Tract.
Por que acontece
Higher gastric pH decreases atazanavir solubility and absorption.
O que fazer
Avoid PPIs in treatment-experienced patients on atazanavir. In treatment-naive patients follow labeling for a low PPI dose about 12 hours before boosted atazanavir, or choose another antiretroviral.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Dexlansoprazole Grave
- Dacomitinib + Dexlansoprazole Grave
- Dasatinib + Dexlansoprazole Grave
- Dexlansoprazole + Erlotinib Grave
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Dexlansoprazole?
MediHelp rates the interaction as major. Atazanavir and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir absorption depends on gastric acidity, and dexlansoprazole can markedly lower atazanavir concentrations. This risks loss of virologic suppression and resistance.
How serious is the interaction between Atazanavir and Dexlansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients on atazanavir. In treatment-naive patients follow labeling for a low PPI dose about 12 hours before boosted atazanavir, or choose another antiretroviral.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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