Interações medicamentosas
Acalabrutinib + Esomeprazole
Gravidade: Grave
Acalabrutinib and Esomeprazole: major interaction.
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Resumo
Esomeprazole can substantially lower absorption of acalabrutinib tablets or capsules, which may weaken its anticancer effect. Because PPI acid suppression lasts a long time, separating the doses does not reliably prevent this.
O que esta interação significa em palavras simples
Acalabrutinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
Por que acontece
Higher gastric pH reduces the pH-dependent solubility and absorption of acalabrutinib.
O que fazer
Avoid PPIs with acalabrutinib. If acid suppression is needed, use an antacid taken 2 hours apart or an H2 blocker with acalabrutinib taken 2 hours before it, or switch to the tablet form, which is less affected.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Esomeprazole
- Esomeprazole + Mavacamten Contraindicada
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- Atazanavir + Esomeprazole Grave
- Citalopram + Esomeprazole Grave
- Clopidogrel + Esomeprazole Grave
- Dacomitinib + Esomeprazole Grave
Outras interações de Acalabrutinib
Perguntas frequentes
Can I take Acalabrutinib with Esomeprazole?
MediHelp rates the interaction as major. Acalabrutinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esomeprazole can substantially lower absorption of acalabrutinib tablets or capsules, which may weaken its anticancer effect. Because PPI acid suppression lasts a long time, separating the doses does not reliably prevent this.
How serious is the interaction between Acalabrutinib and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with acalabrutinib. If acid suppression is needed, use an antacid taken 2 hours apart or an H2 blocker with acalabrutinib taken 2 hours before it, or switch to the tablet form, which is less affected.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Esomeprazole page.
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