Interações medicamentosas
Dacomitinib + Esomeprazole
Gravidade: Grave
Dacomitinib and Esomeprazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Esomeprazole lowers dacomitinib exposure, which may reduce its effectiveness in lung cancer. The effect is mainly loss of efficacy rather than toxicity.
O que esta interação significa em palavras simples
Dacomitinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
Por que acontece
Sustained gastric acid suppression by the PPI decreases the absorption of dacomitinib.
O que fazer
Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or give dacomitinib at least 6 hours before or 10 hours after an H2-receptor antagonist.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Dacomitinib e Esomeprazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Esomeprazole
- Esomeprazole + Mavacamten Contraindicada
- Esomeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Esomeprazole Grave
- Atazanavir + Esomeprazole Grave
- Citalopram + Esomeprazole Grave
- Clopidogrel + Esomeprazole Grave
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Amitriptyline + Dacomitinib Grave
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Desipramine Grave
Perguntas frequentes
Can I take Dacomitinib with Esomeprazole?
MediHelp rates the interaction as major. Dacomitinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esomeprazole lowers dacomitinib exposure, which may reduce its effectiveness in lung cancer. The effect is mainly loss of efficacy rather than toxicity.
How serious is the interaction between Dacomitinib and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or give dacomitinib at least 6 hours before or 10 hours after an H2-receptor antagonist.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
