Interações medicamentosas
Esomeprazole + Rilpivirine
Gravidade: Contraindicada
Esomeprazole and Rilpivirine: contraindicated interaction.
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Resumo
Esomeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.
O que esta interação significa em palavras simples
Esomeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Esomeprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Por que acontece
Elevated gastric pH reduces absorption of oral rilpivirine, which needs an acidic environment.
O que fazer
Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Esomeprazole
- Esomeprazole + Mavacamten Contraindicada
- Acalabrutinib + Esomeprazole Grave
- Atazanavir + Esomeprazole Grave
- Citalopram + Esomeprazole Grave
- Clopidogrel + Esomeprazole Grave
- Dacomitinib + Esomeprazole Grave
Outras interações de Rilpivirine
- Carbamazepine + Rilpivirine Contraindicada
- Dexamethasone + Rilpivirine Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Efavirenz + Rilpivirine Contraindicada
- Eslicarbazepine + Rilpivirine Contraindicada
- Lansoprazole + Rilpivirine Contraindicada
Perguntas frequentes
Can I take Esomeprazole with Rilpivirine?
MediHelp rates the interaction as contraindicated. Esomeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Esomeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.
How serious is the interaction between Esomeprazole and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Acalabrutinib, Atazanavir. The full list is on the Esomeprazole page.
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