Interações medicamentosas
Acalabrutinib + Pyrimethamine
Gravidade: Moderada
Acalabrutinib and Pyrimethamine: moderate interaction.
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Resumo
Pyrimethamine is a folate antagonist that can cause bone marrow suppression, and acalabrutinib can cause cytopenias such as neutropenia and thrombocytopenia. Combined use may increase the risk of myelosuppression.
O que esta interação significa em palavras simples
Acalabrutinib and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Pyrimethamine belongs to Anti Parasitic.
Por que acontece
Additive myelosuppressive effects; pyrimethamine inhibits dihydrofolate reductase.
O que fazer
Monitor complete blood counts regularly. Give folinic acid with pyrimethamine as indicated and reduce or interrupt doses if cytopenias develop.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Pyrimethamine
- Deferiprone + Pyrimethamine Grave
- Eliglustat + Pyrimethamine Grave
- Brexpiprazole + Pyrimethamine Moderada
- Dapsone + Pyrimethamine Moderada
- Folic acid + Pyrimethamine Moderada
- Fosphenytoin + Pyrimethamine Moderada
Outras interações de Acalabrutinib
Perguntas frequentes
Can I take Acalabrutinib with Pyrimethamine?
MediHelp rates the interaction as moderate. Acalabrutinib and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine is a folate antagonist that can cause bone marrow suppression, and acalabrutinib can cause cytopenias such as neutropenia and thrombocytopenia. Combined use may increase the risk of myelosuppression.
How serious is the interaction between Acalabrutinib and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Give folinic acid with pyrimethamine as indicated and reduce or interrupt doses if cytopenias develop.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Brexpiprazole. The full list is on the Pyrimethamine page.
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