Interações medicamentosas
Eliglustat + Pyrimethamine
Gravidade: Grave
Eliglustat and Pyrimethamine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Pyrimethamine is reported to inhibit CYP2D6, which could raise eliglustat exposure. Eliglustat can prolong PR, QTc and QRS intervals at high concentrations, so increased exposure raises arrhythmia risk.
O que esta interação significa em palavras simples
Eliglustat and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
Por que acontece
Possible CYP2D6 inhibition by pyrimethamine reduces eliglustat clearance.
O que fazer
Avoid if possible; otherwise reduce the eliglustat dose per labeling for CYP2D6 inhibitors and monitor the ECG. Do not combine with any CYP3A inhibitor.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Eliglustat e Pyrimethamine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Pyrimethamine
- Deferiprone + Pyrimethamine Grave
- Acalabrutinib + Pyrimethamine Moderada
- Brexpiprazole + Pyrimethamine Moderada
- Dapsone + Pyrimethamine Moderada
- Folic acid + Pyrimethamine Moderada
- Fosphenytoin + Pyrimethamine Moderada
Outras interações de Eliglustat
- Amiodarone + Eliglustat Contraindicada
- Clarithromycin + Eliglustat Contraindicada
- Dronedarone + Eliglustat Contraindicada
- Eliglustat + Itraconazole Contraindicada
- Eliglustat + Ketoconazole Contraindicada
- Eliglustat + Pimozide Contraindicada
Perguntas frequentes
Can I take Eliglustat with Pyrimethamine?
MediHelp rates the interaction as major. Eliglustat and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pyrimethamine is reported to inhibit CYP2D6, which could raise eliglustat exposure. Eliglustat can prolong PR, QTc and QRS intervals at high concentrations, so increased exposure raises arrhythmia risk.
How serious is the interaction between Eliglustat and Pyrimethamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the eliglustat dose per labeling for CYP2D6 inhibitors and monitor the ECG. Do not combine with any CYP3A inhibitor.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Acalabrutinib, Brexpiprazole. The full list is on the Pyrimethamine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
