Interações medicamentosas
Brexpiprazole + Pyrimethamine
Gravidade: Moderada
Brexpiprazole and Pyrimethamine: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Pyrimethamine may raise brexpiprazole exposure by inhibiting its CYP2D6 metabolism. Higher levels could increase sedation, akathisia, orthostatic hypotension and other adverse effects, especially if a CYP3A4 inhibitor is also given.
O que esta interação significa em palavras simples
Brexpiprazole and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
Por que acontece
Inhibition of CYP2D6-mediated metabolism of brexpiprazole.
O que fazer
Monitor for adverse effects of brexpiprazole during co-use. Reduce the brexpiprazole dose to a quarter of usual if a strong or moderate CYP3A4 inhibitor is also given with a CYP2D6 inhibitor.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Pyrimethamine
- Deferiprone + Pyrimethamine Grave
- Eliglustat + Pyrimethamine Grave
- Acalabrutinib + Pyrimethamine Moderada
- Dapsone + Pyrimethamine Moderada
- Folic acid + Pyrimethamine Moderada
- Fosphenytoin + Pyrimethamine Moderada
Outras interações de Brexpiprazole
Perguntas frequentes
Can I take Brexpiprazole with Pyrimethamine?
MediHelp rates the interaction as moderate. Brexpiprazole and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine may raise brexpiprazole exposure by inhibiting its CYP2D6 metabolism. Higher levels could increase sedation, akathisia, orthostatic hypotension and other adverse effects, especially if a CYP3A4 inhibitor is also given.
How serious is the interaction between Brexpiprazole and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of brexpiprazole during co-use. Reduce the brexpiprazole dose to a quarter of usual if a strong or moderate CYP3A4 inhibitor is also given with a CYP2D6 inhibitor.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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