Interações medicamentosas
Dapsone + Pyrimethamine
Gravidade: Moderada
Dapsone and Pyrimethamine: moderate interaction.
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Resumo
Dapsone and pyrimethamine are used together for toxoplasmosis and malaria prophylaxis, but both can cause hematologic toxicity. Pyrimethamine is an antifolate that can cause bone marrow suppression, and dapsone can cause hemolysis and methemoglobinemia. The combination increases the risk of anemia, neutropenia and thrombocytopenia.
O que esta interação significa em palavras simples
Dapsone and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Pyrimethamine belongs to Anti Parasitic.
Por que acontece
Additive hematologic toxicity: antifolate marrow suppression from pyrimethamine plus oxidative hemolysis from dapsone.
O que fazer
Screen for G6PD deficiency and monitor complete blood counts regularly. Give folinic acid with pyrimethamine as recommended in treatment protocols.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dapsone
- Bcg vaccine live + Dapsone Grave
- Dapsone + Primaquine Grave
- Apalutamide + Dapsone Moderada
- Belzutifan + Dapsone Moderada
- Bosentan + Dapsone Moderada
- Bupivacaine implant + Dapsone Moderada
Outras interações de Pyrimethamine
- Deferiprone + Pyrimethamine Grave
- Eliglustat + Pyrimethamine Grave
- Acalabrutinib + Pyrimethamine Moderada
- Brexpiprazole + Pyrimethamine Moderada
- Folic acid + Pyrimethamine Moderada
- Fosphenytoin + Pyrimethamine Moderada
Perguntas frequentes
Can I take Dapsone with Pyrimethamine?
MediHelp rates the interaction as moderate. Dapsone and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapsone and pyrimethamine are used together for toxoplasmosis and malaria prophylaxis, but both can cause hematologic toxicity. Pyrimethamine is an antifolate that can cause bone marrow suppression, and dapsone can cause hemolysis and methemoglobinemia. The combination increases the risk of anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Dapsone and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for G6PD deficiency and monitor complete blood counts regularly. Give folinic acid with pyrimethamine as recommended in treatment protocols.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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