Interações medicamentosas
Acemetacin + Mesalamine
Gravidade: Moderada
Acemetacin and Mesalamine: moderate interaction.
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Resumo
Mesalamine can rarely cause interstitial nephritis and NSAIDs such as acemetacin impair renal prostaglandin-dependent perfusion. Together they may increase the risk of kidney injury, especially with dehydration or existing renal disease.
O que esta interação significa em palavras simples
Acemetacin and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxicity through NSAID-mediated renal hemodynamic effects and mesalamine-related interstitial nephritis.
O que fazer
Monitor serum creatinine and urine output at baseline and periodically. Avoid combining in patients with renal impairment.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Mesalamine
Perguntas frequentes
Can I take Acemetacin with Mesalamine?
MediHelp rates the interaction as moderate. Acemetacin and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can rarely cause interstitial nephritis and NSAIDs such as acemetacin impair renal prostaglandin-dependent perfusion. Together they may increase the risk of kidney injury, especially with dehydration or existing renal disease.
How serious is the interaction between Acemetacin and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output at baseline and periodically. Avoid combining in patients with renal impairment.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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