Interações medicamentosas
Mesalamine + Varicella virus vaccine live
Gravidade: Grave
Mesalamine and Varicella virus vaccine live: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Mesalamine is a 5-aminosalicylate, and salicylate use after live varicella vaccination has been linked to Reye's syndrome in children. Systemic salicylate exposure from mesalamine is low, so the risk is theoretical but is included in labeling.
O que esta interação significa em palavras simples
Mesalamine and Varicella virus vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Salicylate exposure after live varicella virus vaccination is thought to predispose to Reye's syndrome; the precise mechanism is not established.
O que fazer
Avoid salicylate-containing products, including mesalamine, for about 6 weeks after vaccination in children and adolescents where possible. If mesalamine is essential, weigh the risks and benefits and counsel caregivers to report vomiting or altered behavior.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Mesalamine
Perguntas frequentes
Can I take Mesalamine with Varicella virus vaccine live?
MediHelp rates the interaction as major. Mesalamine and Varicella virus vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mesalamine is a 5-aminosalicylate, and salicylate use after live varicella vaccination has been linked to Reye's syndrome in children. Systemic salicylate exposure from mesalamine is low, so the risk is theoretical but is included in labeling.
How serious is the interaction between Mesalamine and Varicella virus vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid salicylate-containing products, including mesalamine, for about 6 weeks after vaccination in children and adolescents where possible. If mesalamine is essential, weigh the risks and benefits and counsel caregivers to report vomiting or altered behavior.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Aceclofenac, Acemetacin. The full list is on the Mesalamine page.
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