Interações medicamentosas
Aspirin rectal + Mesalamine
Gravidade: Moderada
Aspirin rectal and Mesalamine: moderate interaction.
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Resumo
Mesalamine can rarely cause interstitial nephritis and rectal aspirin delivers systemic salicylate that can reduce renal prostaglandin-dependent perfusion. Together they may increase the risk of kidney injury.
O que esta interação significa em palavras simples
Aspirin rectal and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxicity through salicylate-related renal effects and mesalamine-related interstitial nephritis.
O que fazer
Monitor serum creatinine periodically, particularly with repeated aspirin doses or renal impairment.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Mesalamine
Perguntas frequentes
Can I take Aspirin rectal with Mesalamine?
MediHelp rates the interaction as moderate. Aspirin rectal and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can rarely cause interstitial nephritis and rectal aspirin delivers systemic salicylate that can reduce renal prostaglandin-dependent perfusion. Together they may increase the risk of kidney injury.
How serious is the interaction between Aspirin rectal and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine periodically, particularly with repeated aspirin doses or renal impairment.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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