Interações medicamentosas
Alfentanil + Codeine
Gravidade: Grave
Alfentanil and Codeine: major interaction.
Última atualização
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Resumo
Both are opioid agonists, so combined use increases sedation, respiratory depression and hypotension. The risk is highest with higher doses or in opioid-naive or elderly patients.
O que esta interação significa em palavras simples
Alfentanil and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive mu-opioid receptor mediated CNS and respiratory depression.
O que fazer
Avoid unplanned combinations; if used, lower doses and monitor respiratory rate and sedation closely. Ensure naloxone and ventilatory support are available in procedural settings.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Codeine
- Alvimopan + Codeine Contraindicada
- Codeine + Isocarboxazid Contraindicada
- Codeine + Olanzapine / samidorphan Contraindicada
- Codeine + Phenelzine Contraindicada
- Codeine + Tranylcypromine Contraindicada
- Alprazolam + Codeine Grave
Perguntas frequentes
Can I take Alfentanil with Codeine?
MediHelp rates the interaction as major. Alfentanil and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are opioid agonists, so combined use increases sedation, respiratory depression and hypotension. The risk is highest with higher doses or in opioid-naive or elderly patients.
How serious is the interaction between Alfentanil and Codeine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unplanned combinations; if used, lower doses and monitor respiratory rate and sedation closely. Ensure naloxone and ventilatory support are available in procedural settings.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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