Interações medicamentosas
Alvimopan + Codeine
Gravidade: Contraindicada
Alvimopan and Codeine: contraindicated interaction.
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Resumo
Alvimopan antagonises peripheral mu-opioid receptors, and patients who have taken opioids for more than 7 days can have exaggerated gastrointestinal effects including pain, nausea, vomiting and diarrhea. Short-term perioperative opioid use is not expected to be problematic.
O que esta interação significa em palavras simples
Alvimopan and Codeine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Competitive antagonism of peripheral mu-opioid receptors by alvimopan.
O que fazer
Do not use alvimopan in patients with therapeutic opioid use for more than 7 consecutive days before starting it. Short-term opioid exposure does not require avoidance.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Codeine
- Codeine + Isocarboxazid Contraindicada
- Codeine + Olanzapine / samidorphan Contraindicada
- Codeine + Phenelzine Contraindicada
- Codeine + Tranylcypromine Contraindicada
- Alfentanil + Codeine Grave
- Alprazolam + Codeine Grave
Perguntas frequentes
Can I take Alvimopan with Codeine?
MediHelp rates the interaction as contraindicated. Alvimopan and Codeine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have taken opioids for more than 7 days can have exaggerated gastrointestinal effects including pain, nausea, vomiting and diarrhea. Short-term perioperative opioid use is not expected to be problematic.
How serious is the interaction between Alvimopan and Codeine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients with therapeutic opioid use for more than 7 consecutive days before starting it. Short-term opioid exposure does not require avoidance.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.
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