Interações medicamentosas
Codeine + Isocarboxazid
Gravidade: Contraindicada
Codeine and Isocarboxazid: contraindicated interaction.
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Resumo
MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.
O que esta interação significa em palavras simples
Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Codeine belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
Por que acontece
MAO inhibition increases monoamine levels and potentiates opioid effects, with an incompletely understood mechanism.
O que fazer
Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Codeine
- Alvimopan + Codeine Contraindicada
- Codeine + Olanzapine / samidorphan Contraindicada
- Codeine + Phenelzine Contraindicada
- Codeine + Tranylcypromine Contraindicada
- Alfentanil + Codeine Grave
- Alprazolam + Codeine Grave
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Codeine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.
How serious is the interaction between Codeine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.
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