Interações medicamentosas
Codeine + Tranylcypromine
Gravidade: Contraindicada
Codeine and Tranylcypromine: contraindicated interaction.
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Resumo
Tranylcypromine, a nonselective MAOI, combined with codeine can cause serotonin syndrome or an opioid-MAOI reaction with hyperthermia, blood pressure instability, coma and respiratory depression, which may be fatal.
O que esta interação significa em palavras simples
Codeine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Codeine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Por que acontece
Irreversible MAO inhibition combined with opioid serotonergic and CNS depressant effects.
O que fazer
Do not use codeine during or within 14 days of stopping tranylcypromine. Use a non-serotonergic analgesic.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Codeine
- Alvimopan + Codeine Contraindicada
- Codeine + Isocarboxazid Contraindicada
- Codeine + Olanzapine / samidorphan Contraindicada
- Codeine + Phenelzine Contraindicada
- Alfentanil + Codeine Grave
- Alprazolam + Codeine Grave
Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Codeine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Codeine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine, a nonselective MAOI, combined with codeine can cause serotonin syndrome or an opioid-MAOI reaction with hyperthermia, blood pressure instability, coma and respiratory depression, which may be fatal.
How serious is the interaction between Codeine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine during or within 14 days of stopping tranylcypromine. Use a non-serotonergic analgesic.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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