Interações medicamentosas
Amikacin + Cefazolin
Gravidade: Moderada
Amikacin and Cefazolin: moderate interaction.
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Resumo
Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.
O que esta interação significa em palavras simples
Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefazolin belongs to Anti Bacterial.
Por que acontece
Possible additive renal tubular injury; aminoglycoside toxicity is the dominant contributor.
O que fazer
Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefazolin
- Bcg vaccine live + Cefazolin Moderada
- Cefazolin + Cholera vaccine Moderada
- Cefazolin + Dexamethasone-tobramycin Moderada
- Cefazolin + Gentamicin Moderada
- Cefazolin + Kanamycin Moderada
- Cefazolin + Microbiota Moderada
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Cefazolin?
MediHelp rates the interaction as moderate. Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.
How serious is the interaction between Amikacin and Cefazolin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Bcg vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefazolin page.
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