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Interações medicamentosas

Cefazolin + Cholera vaccine

Gravidade: Moderada

Cefazolin and Cholera vaccine: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

The oral live attenuated cholera vaccine can be inactivated by active antibiotics, reducing immune response. A single perioperative cefazolin dose is less likely to matter but the labeling advice still applies.

O que esta interação significa em palavras simples

Cefazolin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Nível de evidência: Moderate

Por que acontece

Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.

O que fazer

Avoid vaccination within 14 days of systemic antibiotic use, as per labeling; defer the vaccine until the course is completed.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefazolin with Cholera vaccine?

MediHelp rates the interaction as moderate. Cefazolin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine can be inactivated by active antibiotics, reducing immune response. A single perioperative cefazolin dose is less likely to matter but the labeling advice still applies.

How serious is the interaction between Cefazolin and Cholera vaccine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days of systemic antibiotic use, as per labeling; defer the vaccine until the course is completed.

What other medicines interact with Cefazolin?

MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Dexamethasone-tobramycin. The full list is on the Cefazolin page.

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