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Interações medicamentosas

Cefazolin + Dexamethasone-tobramycin

Gravidade: Moderada

Cefazolin and Dexamethasone-tobramycin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Cefazolin with an aminoglycoside has been linked to additive kidney injury in some reports, though cefazolin itself is rarely nephrotoxic. Risk is greater with pre-existing renal impairment.

O que esta interação significa em palavras simples

Cefazolin and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefazolin belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Possible additive nephrotoxicity; mechanism not firmly established.

O que fazer

Monitor serum creatinine and tobramycin concentrations, and adjust doses for renal function.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefazolin with Dexamethasone-tobramycin?

MediHelp rates the interaction as moderate. Cefazolin and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefazolin with an aminoglycoside has been linked to additive kidney injury in some reports, though cefazolin itself is rarely nephrotoxic. Risk is greater with pre-existing renal impairment.

How serious is the interaction between Cefazolin and Dexamethasone-tobramycin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin concentrations, and adjust doses for renal function.

What other medicines interact with Dexamethasone-tobramycin?

MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.

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