Interações medicamentosas
Cefazolin + Kanamycin
Gravidade: Moderada
Cefazolin and Kanamycin: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Cefazolin given with an aminoglycoside such as kanamycin has been associated with a possible additive risk of kidney injury, and aminoglycosides also carry ototoxic risk. Kanamycin is itself markedly nephrotoxic and ototoxic, so any added renal impairment raises aminoglycoside exposure and toxicity.
O que esta interação significa em palavras simples
Cefazolin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxic potential, with reduced renal clearance of the aminoglycoside if kidney function declines.
O que fazer
Monitor serum creatinine and urine output and aminoglycoside levels where applicable during combined use. Adjust the kanamycin dose to renal function and watch for hearing or vestibular symptoms.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefazolin
- Amikacin + Cefazolin Moderada
- Bcg vaccine live + Cefazolin Moderada
- Cefazolin + Cholera vaccine Moderada
- Cefazolin + Dexamethasone-tobramycin Moderada
- Cefazolin + Gentamicin Moderada
- Cefazolin + Microbiota Moderada
Perguntas frequentes
Can I take Cefazolin with Kanamycin?
MediHelp rates the interaction as moderate. Cefazolin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefazolin given with an aminoglycoside such as kanamycin has been associated with a possible additive risk of kidney injury, and aminoglycosides also carry ototoxic risk. Kanamycin is itself markedly nephrotoxic and ototoxic, so any added renal impairment raises aminoglycoside exposure and toxicity.
How serious is the interaction between Cefazolin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output and aminoglycoside levels where applicable during combined use. Adjust the kanamycin dose to renal function and watch for hearing or vestibular symptoms.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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