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Interações medicamentosas

Amikacin + Cefpirome

Gravidade: Moderada

Amikacin and Cefpirome: moderate interaction.

Última atualização

Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Concurrent cephalosporins and aminoglycosides have been associated with greater kidney injury in some reports. The effect is generally modest but may matter in patients with existing renal impairment.

O que esta interação significa em palavras simples

Amikacin and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amikacin belongs to Anti Bacterial; Cefpirome belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Possible additive nephrotoxicity.

O que fazer

Monitor serum creatinine and amikacin concentrations, keep patients well hydrated, and adjust the amikacin dose to renal function.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Amikacin with Cefpirome?

MediHelp rates the interaction as moderate. Amikacin and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent cephalosporins and aminoglycosides have been associated with greater kidney injury in some reports. The effect is generally modest but may matter in patients with existing renal impairment.

How serious is the interaction between Amikacin and Cefpirome?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin concentrations, keep patients well hydrated, and adjust the amikacin dose to renal function.

What other medicines interact with Amikacin?

MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.

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