Interações medicamentosas
Cefpirome + Gentamicin
Gravidade: Moderada
Cefpirome and Gentamicin: moderate interaction.
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Resumo
Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though the effect is generally modest with newer agents. Concurrent use may modestly raise the risk of renal impairment, particularly in patients with existing kidney disease or dehydration.
O que esta interação significa em palavras simples
Cefpirome and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpirome belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Por que acontece
Possible additive renal tubular injury; the mechanism is not firmly established.
O que fazer
Monitor serum creatinine during combined therapy and adjust doses to renal function. Check gentamicin levels in patients at risk.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Gentamicin
Outras interações de Cefpirome
- Amikacin + Cefpirome Moderada
- Bupropion-naltrexone + Cefpirome Moderada
- Bupropion + Cefpirome Moderada
- Cefpirome + Dexamethasone-tobramycin Moderada
- Cefpirome + Streptomycin Moderada
- Acetylsalicylic acid + Cefpirome Leve
Perguntas frequentes
Can I take Cefpirome with Gentamicin?
MediHelp rates the interaction as moderate. Cefpirome and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though the effect is generally modest with newer agents. Concurrent use may modestly raise the risk of renal impairment, particularly in patients with existing kidney disease or dehydration.
How serious is the interaction between Cefpirome and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during combined therapy and adjust doses to renal function. Check gentamicin levels in patients at risk.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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